Vijay Kotra, S. Ganapaty, S. Adapa
Dec 21, 2010
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Influential Citations
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Quality indicators
Journal
ChemInform
Abstract
A new series of quinolinyl chalcone derivatives (SGCH 1-20) have been synthesized by the reaction of quinolinyl and chloroquinolinyl acetophenones with substituted aromatic aldehydes. These compounds have been characterized by IR, H NMR, mass spectral and elemental analysis. The compounds have been found to exhibit anticancer and anti-inflammatory activities. Among the compounds tested for anticancer activity on RAW cell lines by MTT assay, compound SGCH 3 (3-(4chlorophenyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1-one) show more percentage of inhibition upto 103%. With regard to the anti-inflammatory activity, compound SGCH 9 (3-(2-furyl)-1-(3-methyl-1-phenyl-2-naphthyl)-2-propen-1one), SGCH 10 (3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen-1-one), SGCH 19 (1-(7-chloro-3-methyl-1-phenyl2-naphthyl)-3-(2-furyl)-2-propen-1-one) and SGCH 20 (1-(7-chloro-3-methyl-1-phenyl-2-naphthyl)-3-(2-thienyl)-2-propen1-one) have been found to significant reduction in rat paw oedema when compared to the other compounds.