M. Shaban, A. E. Morgaan
1999
Citations
0
Influential Citations
34
Citations
Journal
Advances in Heterocyclic Chemistry
Abstract
Publisher Summary This chapter reviews the chemistry of 1,2,4-triazolopyrimidines. The chapter is devoted to surveying the chemistry of one of the four possible systems of this class of compounds—namely, 1,2,4-triazolo[4,3-a]pyrimidin. The chapter focuses on the chemistry of 1,2,4-triazolo[1,5-c]pyrimidines. This chapter discusses the introduction, synthesis, reactions, spectral properties, and applications of 1,2,4-triazolopyrimidines 11: 1,2,4-triazolo[4,3-c]pyrimidines. It also illustrates that many members of the 1,2,4-triazoIo[4,3-c]pyrimidines are shown to possess very interesting biological activities and medicinal applications. The chapter concludes by discussing that 1,2,4-triazoIo[4,3-c]pyrimidines have been synthesized using several general approaches: (1)annulation of the 1,2,4-triazole ring onto a pyrimidine structure; (2) annulation of the pyrimidine ring onto a 1,2,4-triazole structure; (3) concurrent formation of both of the 1,2,4-triazole and pyrimidine rings; and (4) rearrangement of pyrimido[5,4-e]l,2,4-triazines.