M. Gouda, G. G. El-Bana
Mar 28, 2022
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Journal
Mini-Reviews in Organic Chemistry
Abstract
This review described the preparation of 2-chloroquinoline-3-carbaldehyde derivatives, through Vilsmeier-Haack formylation of N-arylacetamides and used them as a key intermediate for preparation of 2-(piperidin-1-yl) and/ or 2-(morpholin-1-yl) quinoline-3-carbaldehydes. The synthesis of the 2-(piperidin-1-yl) and/ or 2-(morpholin-1-yl) quinolines derivative were explained through the following chemical reactions: reaction with active methyl and/ or methylene component, Claisen-Schmidt condensation, one-pot multicomponent reactions (MCRs), reductive amination, Grignard reaction, etc….