W. Dai, K. W. Lai
Dec 16, 2002
Citations
0
Influential Citations
59
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The first synthesis of 4-, 5-, and 6-nitrobenzo[b]furans has been achieved via the Sonogashira cross-coupling reaction of 2-iodonitrophenol acetates prepared from commercially available and inexpensive 2-aminonitrophenols. The obtained 2-alkynylnitrophenol acetates were subjected to a KOtBu-promoted cyclization at room temperature to form nitrobenzo[b]furans. Examples of the synthesis of other substituted benzo[b]furans and the one-pot coupling–cyclization are given.