W. Cunico, C. Gomes, W. T. Vellasco
Oct 31, 2008
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Influential Citations
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ChemInform
Abstract
Abstract: 1,3-Thiazolidin-4-ones are an important group of heterocyclic compounds that are used in the field of medicinal chemistry. The utility of 1,3-thiazolidin-4-ones as synthons for various biological compounds has given impetus to these studies. In recent years, 1,3-thiazoldin-4-ones have been among the most extensively studied compounds. This review aims to review the work reported on the chemistry and biological activities of 1,3-thiazolidin-4-ones during the past few years. INTRODUCTION There are numerous biologically active molecules with five-membered rings, containing two hetero atoms. Thiazolidinone is an important scaffold known to be associated with several biological activities. A comprehensive review has been written on 4-thiazo-lidinones in 1981 [1]. 1,3-Thiazolidin-4-ones are heterocycles that have an atom of sul-fur at position 1, an atom of nitrogen at position 3 and a carbonyl group at position 4 (Fig. 1 ). Substituents in the 2-,3-, and 5-position may be varied, but in this review we focused only modifications in the positions 2 and 3. Numerous methods for the synthesis of thia-zolidinones and also their diverse reactions offer enormous scope in the field of medicinal chemistry. We present here the chemistry and biological properties of this heterocyclic ring since 2000. wave dielectric heating for the preparation of a small library of 1,3-1