Ryoko Toyoshima, Nanae Mori, Toshihiro Suzuki
Jul 1, 2016
Citations
0
Influential Citations
4
Citations
Journal
Chemical & pharmaceutical bulletin
Abstract
Eleven 2'-N-acyl derivatives (5a-k) were prepared from ecteinascidin 770 (Et 770: 1b) via known 18,6'-O-bisallyl-protected compound (3) in three steps. Their in vitro cytotoxicities were determined by measuring IC50 values against human cell lines HCT116 and DU145. 5-Isoxazolecarboylamide derivative (5i) and 4-methoxybenzoylamide derivative (5k) were found to be promising leads for further optimization.