O. Lefebvre, T. Brigaud, C. Portella*
May 28, 1998
Citations
0
Influential Citations
41
Citations
Journal
Tetrahedron
Abstract
Abstract We describe the synthesis of 2,2-difluoro-1,5-diketones in a one-pot procedure from an acylsilane and trifluoromethyltrimethylsilane, via reaction of difluoroenoxysilanes and enones under electrophilic activation. These diketones are interesting building blocks for the synthesis of gem -difluoro enones or substituted fluorophenols, depending on the annulation conditions. The annulation proceeds with complete regioselectivity controlled by the fluorine substitution.