L. Klemm, R. E. Merrill, F. H. Lee
Apr 1, 1974
Citations
0
Influential Citations
21
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
Thieno [2,3-b] pyridine (Ia) was converted into its 3-chloro, 3-bromo, and 3-iodo derivatives by means of elemental halogen, silver sulfate, and sulfuric acid. Bromine in a buffered chloroform solution of la also gave the 3-bromo compound (57% yield). Chlorine plus a refluxing mixture of Ia, chloroform, and water produced both the 3-chloro and the 2,3-dichloro derivatives. Various transformation products of these halothienopyridines (including the 2-nitro-3-halo compounds) are described and mass spectral fragmentation patterns are presented.