N. Boudet, P. Knochel
Jul 18, 2006
Citations
0
Influential Citations
36
Citations
Journal
Organic letters
Abstract
[reaction: see text] A novel route for the synthesis of 4,5-difunctionalized uracils using a chemo- and regioselective bromine/magnesium exchange reaction on 5-bromo-4-halogeno-2,6-dimethoxypyrimidines has been developed. Applications to the synthesis of pharmaceuticals such as oxypurinol and emivirine are reported.