H. Raj, S. Gupta, G. Biswas
Dec 1, 1996
Citations
0
Influential Citations
16
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
Eighteen 4-methylcoumarins bearing methoxy/hydroxy/acetoxy functionalities have been reported to effectively inhibit the rat liver microsome-mediated aflatoxin B1-DNA binding in vitro. The contribution of functionality on coumarin nucleus towards the inhibition of AFB1-DNA binding is in the order acetoxy > hydroxy > methoxy. The results illustrate the structure-activity relationship.