S. Sunitha, S. Kanjilal, P. S. Reddy
Apr 14, 2008
Citations
1
Influential Citations
49
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The first report of a Bronsted acidic ionic liquid, 1-methylimidazolium tetrafluoroborate [(HMIm)BF 4 ], catalyzed efficient and chemoselective N -Boc protection of various amines using (Boc) 2 O is presented. Optically pure amino alcohols and amino acid esters were converted efficiently to their corresponding optically pure N -Boc derivatives. The reported method is mild, solvent-free and has the advantages of both homogeneous and heterogeneous catalysis with high product yields, selectivity and ease of product separation.