A. Kalaiyarasi, J. Haribabu, D. Gayathri
Jun 5, 2019
Citations
0
Influential Citations
14
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract Acylthiourea derivatives, 1-benzoyl-3-(quinolin-8-yl)thiourea (1), 1-(furan-2-carbonyl)-3-(quinolin-8-yl)thiourea (2) and 1-(thiophene-2-carbonyl)-3-(quinolin-8-yl)thiourea (3) were synthesized and well characterized by using NMR (1H and 13C), FT-IR, UV–visible and mass spectroscopy tools. The molecular structures of compounds 1 and 3 were confirmed by single crystal X-ray crystallography. The fluorescence emission of the compounds (1–3) was studied using fluorescence spectrophotometer. The sensing ability of the acylthiourea derivatives was analyzed by colorimetric, UV–visible and fluorescence titrations. In silico anti-inflammatory, antimalarial and anti-tuberculosis activities were investigated using molecular docking studies. Acylthiourea derivatives also possessed good antioxidant activity.