B. S. Kulkarni, B. Fernandez, M. Patel
Jul 1, 1969
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Nearly eighty substituted thiocarbanilides–viz., p -(2-thiazolyl)-, p -(4-thiazolyl)- and p -(5-thiazolyl)- p -alkoxy-thiocarbanilides, and p - p ′-bis(4-thiazolyl)-thiocarbanilides, along with a few thiazolyl thiocarbanilides having halogens on the phenyl ring containing the p ′-alkoxy group, have been synthesized and studied for in vitro antitubercular activity. Also described are over 40 new substituted thiazoles prepared as intermediates. p -(4-Thiazolyl)- p ′- alkoxy-thiocarbanilides in general showed the maximum in vitro tuberculostatic activity in the present study. p -(2,5-Dimethyl-4-thiazolyl)- p ′- n -propoxythiocarbanilide had the same in vitro tuberculostatic activity as isonicotinic acid hydrazide ( INH ) (0.04 mcg./ml.) but did not produce tuberculostatic serum concentration at the same oral dose level as INH .