A. Lee, W. Chan, Yi-Wen Tao
1994
Citations
0
Influential Citations
16
Citations
Journal
Journal of The Chemical Society-perkin Transactions 1
Abstract
Michael addition of 2-(3,4-dimethoxyphenyl)ethylamine 3 or tryptamine 4 onto chiral acetylenic sulfoxides 2 followed by acid induced cyclization afforded the basic alkaloid skeleton of tetraisoquinoline and tetrahydro-β-carboline in high to moderate diastereoselectivity. Optically pure (R)(+)-Carnegine and (R)-(+)-tetrahydroharman have been synthesized.