A. DuruI., I. NgochindoR., E. DuruC.
2014
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0
Influential Citations
1
Citations
Quality indicators
Journal
IOSR Journal of Applied Chemistry
Abstract
dichloroimidazole (DCI) was synthesized and characterized using spectroscopic methods. The compound and its complexes did not show any significant antibacterial activity against Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa and Proteus spp, when compared with the good activity shown by imidazole which is its precursor compound. Imidazole however showed complete inactivity against the fungi strains Aspergillus spp, Candida spp and Trichophyton spp. These fungi were very sensitive to DCI with further sensitivity shown to the Cr 3+ and Co 2+ complexes of the compound. These two complexes of DCI were also more active than the standard antifungal drug ketoconazole in inhibiting the growth of these fungi making them very potent compounds in the search for antifungal agents.