A. I. Tochilkin, I. N. Gracheva, I. R. Kovel'man
1983
Citations
0
Influential Citations
5
Citations
Journal
Chemistry of Heterocyclic Compounds
Abstract
Abstract5-Chloro- and 5-iodo-8-methylquinoline were obtained by chlorination or iodination of 8-methylquinoline with chlorine or iodine in concentrated sulfuric acid in the presence of silver sulfate. 5-Fluoro-8-methylquinoline was synthesized from 5-amino-8-methylquinoline. 5-Chloro-, 5-bromo-, and 5-fluoro-8-methylquinoline were converted to the corresponding 5-halo-8-(bromomethyl)quinolines by bromination with N-bromosuccinimide. Partial displacement of iodine by bromine to give a mixture of 5-bromo- and 5-iodo-8-(bromomethyl)quinoline occurs in the analogous bromination of 5-iodo-8-methylquinoline.