Li‐Wen Xu, W. Zhou, Lei Yang
Sep 1, 2007
Citations
0
Influential Citations
15
Citations
Journal
Synthetic Communications
Abstract
Abstract Catalytic amount of chlorotrimethylsilane (TMSCl) was found to be an effective silicon Lewis acid catalyst in catalyzing the Michael‐type Friedel–Crafts reactions of indoles and chalcones to afford corresponding 3‐substituted indole derivatives in good to excellent yields. The method is metal‐free, has mild reaction conditions, and generates good yields of products with greater selectivity, which make it a useful and attractive process for the synthesis of different indole derivatives.