R. Rosenfeld, B. Zumoff, L. Hellman
1962
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Archives of biochemistry and biophysics
Abstract
Abstract Cholestenone-4-C 14 has been administered orally to six subjects in eight studies for the purpose of comparing its behavior with that of dietary cholesterol. In an additional investigation the tracer was given intravenously. From 0.6 to 8.5% of the ingested dose was accounted for in plasma sterol. The presence of unaltered cholestenone in the blood has been established 4 hr. after oral ingestion of the tracer. At the time of maximum absorption in the plasma, essentially all of the radioactivity was present as cholestanol. From 65 to 100% of the radioactivity had been excreted in the stool after 2 weeks. In one subject, 1.1% was excreted in the urine, but in six other studies urinary excretion amounted to less than 0.2% of the radioactive dose. Cholestanol and coprostanol were the principal sterol transformation products in feces from labeled cholestenone. Cholesterol-C 14 was found only in very small amounts. The results indicate that the dynamic behavior of cholestanol in the plasma resembles that of cholesterol.