M. Rao, P. K. Babu, H. Sharma
2017
Citations
0
Influential Citations
0
Citations
Journal
Asian Journal of Chemistry
Abstract
Chlorinated acetic acids draw attention of various synthetic chemists for its use as intermediates in organic synthesis and for its role as substitution of Cl atoms. Among them chloroacetic acid is widely preferred and most significant industrially [1]. In 1841, initially synthesized as chlorination product [2] of acetic acid, it does not occur in nature. Chloroacetic acid in aqueous solution exists as an anion species, where it doesn’t have any UV photometric absorption. The estimation of chloroacetic acid was not possible in lower limits in drug substances. But, species like anionic nature in lower limits can be easily estimated using the ion chromatographic technique in conductivity detector mode. Isoproterenol (isoprenaline) is a sympathomimetic drug (Fig. 1), which imitate the effect of sympathetic nervous system and act solely on β-adrenergic receptors [3]. This drug is listed in 2004 WHO model list as most essential drug, which used in rare disorder, for the treatment of patients suffering with severe bradycardia i.e. for short term treatment of heart nodal block [4]. Drug is available as injection containing isoproterenol hydrochloride 20 mcg/mL (1-3 mL). It is recommended as bradyarrhythmias and is administered as an intravenous infusion at dose rate of 1-4 mcg/min related to cardiac disorders. Chloroacetic acid is used in the synthesis of basic intermediate 3,4-dihydroxy-α-chloroacetophenone of isoproterenol hydrochloride [5]. Fewer literature methods were available in Ion Chromatographic Method for Determination of Chloroacetic Acid in Isoproterenol Hydrochloride Drug Substance: A Genotoxic Impurity in Trace Levels