U. Hubicka, J. Krzek, M. Stankiewicz
Oct 31, 2009
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Influential Citations
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Journal
Current Pharmaceutical Analysis
Abstract
New chromatographic-densitometric method for determination of clopamide and impurities (4-chlorobenzoic and 4-chloro-3-sulfamoylbenzoic acids) in tablets was developed. Silica gel TLC plates as a stationary phase and n- butanol- 2-propanol -water- methylene chloride (10:7:2:5:3 v/v/v/v/v) as a mobile phase were used for separation. Densi- tometric measurements were done at � = 235 nm. Favourable retention parameters (Rf, Rs, k, � ) were obtained under developed conditions, which guarantee good separation of studied components. Whereas, results that were obtained from validation method confirm specificity, high sensitivity, linearity in a range of studied concentrations, repeatability and good accuracy of this method.