G. B. Lawless, J. Sciarra, A. J. Monte-Bovi
Feb 1, 1965
Citations
0
Influential Citations
5
Citations
Journal
Journal of pharmaceutical sciences
Abstract
A comparison was made of various methods which could be utilized to determine quantitatively various medicinal amines used in a pressurized dosage form. The medicinal amines investigated during this study were atropine N.F., butacaine, ephedrine (anhydrous) N.F., tuaminoheptane, and propylhexedrine U.S.P. The conditions necessary for the chromatographic analysis were established initially using liquid samples of the medicinal amines dissolved in acetone, nitrobenzene, ethanol, and/or chloroform. Once these conditions were established, the aerosol formulation containing the medicinal amine was analyzed by gas chromatography. A procedure for sampling the aerosol was developed, so that those medicinal aerosol products containing amines also could be analyzed by several existing methods of analysis. A titrimetric method was used for each aerosol as a means of comparison for the gas chromatographic analysis. Atropine and butacaine aerosols could not be determined by gas chromatography. Tuaminoheptane and propylhexedrine were assayed by gas chromatography from a nitrobenzene solution, while ephedrine was assayed from an acetone solution. The results of this investigation indicate the effectiveness of these two methods and show their application to the analysis of aerosol products.