Seojeong Park, Soo-Yeon Hwang, Jae-Ho Shin
Oct 22, 2019
Citations
0
Influential Citations
12
Citations
Journal
Chemical communications
Abstract
5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one (compound 52) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg2+, it exhibited highly selective properties against the α-isoform with less toxicity, unlike other topo II poisons, such as etoposide.