L. Kopeloff, J. Chusid, N. Kopeloff
Mar 1, 1954
Citations
1
Influential Citations
58
Citations
Journal
Neurology
Abstract
Aluminum compounds successfully used for the purpose of producing experimental epilepsy have included alums, * alumina, and alumina cream.l Our laboratory has routinely employed a precipitate (alumina cream) prepared according to the method described by Hawk and Bergeim* in which ammonium alum is treated at room temperature with dilute ammonium hydroxide. Such standard preparations of alumina cream have retained their epileptogenic properties for periods of at least two years. Commercial aluminum oxide powder washed with saline, autoclaved, and used as a moist sediment has also been used successfully, and commercially available gelatinous aluminum hydroxide has likewise proved highly effe~tive.~ Linen or fiber disks used to apply the alumina cream were tooled to an inside diameter of 13 mm., a depth of 1.5 mm., and a capacity of approximately 0.2 to 0.25 ml.