C. Traini, G. Cipriani, Stefano Evangelista
Nov 1, 2013
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Influential Citations
12
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Journal
Neurogastroenterology & Motility
Abstract
Otilonium bromide (OB) is a quaternary ammonium derivative used for the treatment of intestinal hypermotility and is endowed with neurokinin2 receptor (NK2r) antagonist and Ca2+channel blocker properties. Therefore, the possibility that OB might play a role in the neurokinin receptor/Substance‐P/nitric oxide (NKr/SP/NO) circuit was investigated after chronic exposition to the drug.