G. Marconi, S. Monti, F. Manoli
Sep 1, 2004
Citations
0
Influential Citations
13
Citations
Journal
Helvetica Chimica Acta
Abstract
The circular dichroism (CD) spectra of the powerful antimalarian active principle artemisinin (ART; 1) from Artemisia annua, and of epiartemisinin (EPI, 2), its C(7) epimer, were studied in solution in the presence and absence of β-cyclodextrin (β-cd). A significant inversion of sign in the region of the second electronic transition was detected. The rotational strengths were successfully calculated within the time-dependent density functional theory (DFT), which enabled us to establish a correlation between the molecular recognition and the biological acitivities of the two isomers.