X. Sheng, Yang Sun, Ye Yin
Nov 1, 2008
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Cirsilineol (4′,5‐dihydroxy‐3′,6,7‐trimethoxyflavone) is a compound isolated from the herb of Artemisia vestita Wall (Compositae). In this study, we aimed at examining the anti‐proliferative activity of cirsilineol against multiple types of cancer cells and the underlying mechanisms. Cirsilineol significantly inhibited proliferation of Caov‐3, Skov‐3, PC3 and Hela cells in a concentration‐dependent manner. The compound also dose‐dependently induced apoptosis in Caov‐3 cells, as determined by annexin V/propidium iodide staining. Besides, cirsilineol induced a remarkable change in mitochondrial membrane potential and caused release of cytochrome c to cytosol. Furthermore, the compound caused a marked activation of capase‐3, caspase‐9 and poly (ADP‐ribose) polymerase (PARP). These results suggested that the induction of apoptosis via the mitochondrial pathway was involved in the anti‐proliferative activity of cirsilineol against cancer cells.