Claudio Battilocchio, G. Poce, S. Alfonso
Jul 1, 2013
Citations
1
Influential Citations
64
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Journal
Bioorganic & medicinal chemistry
Abstract
We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.