D. Ko, Kim Dong-jin, C. Lyu
Jan 15, 1998
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The polymer-sypported synthesis of a methionine-functionalized resin for new cleavage strategy and combinatorial library of homoserine lactone analogs is described. The process consists of the coupling of N-Fmoc-methionine followed by deprotection to give a free amine of methionine-functionalized resin (3). After the coupling with a carboxylic acid, the final cleavage step proceeds through a BrCN-mediated cyclization process to produce homoserine lactone libraries (5) with retention of stereochemistry.