Friederike Danneberg, Alice Ghidini, Plamena Dogandzhiyski
Apr 16, 2015
Citations
1
Influential Citations
25
Citations
Journal
Beilstein Journal of Organic Chemistry
Abstract
Summary Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation occurs with similar rates and substrate specificities as in experiments with DNA conjugates we performed earlier. Although aggregation phenomena are observed in some cases, proper substrate recognition is not compromised. While our previous synthesis of 2-aminobenzimidazoles required an HgO induced cyclization step, a mercury free variant is described herein.