S. Murakami, Cosima Brudy, Moritz Bachmann
Oct 19, 2022
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Journal
Synthesis
Abstract
We report the visible-light photocatalytic cleavage of trityl (thio)ethers under pH-neutral conditions. The method results in the formation of the respective symmetrical disulfides and alcohols in moderate to excellent yield. The protocol only requires the addition of a suitable photocatalyst and light rendering it orthogonal to several functionalities, including acid labile protective groups. The same conditions can be used to directly convert trityl protected thiols into unsymmetrical disulfides or selenylsulfides, and to cleave trityl resins in solid phase organic synthesis.