A. Linden, M. Gündüz, R. Şimşek
Mar 31, 2006
Citations
0
Influential Citations
6
Citations
Journal
Acta crystallographica. Section C, Crystal structure communications
Abstract
A mixture of the RR/SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate, C 19 H 19 Cl 2 NO 3 , forms cocrystals in which there is one unique molecule in the asymmetric unit, but the molecule displays disorder in the region of the 7-position of the quinoline ring system as a result of the random occurrence of the diastereoisomers at the same crystallographic site. A similar arrangement exists in the monohydrate cocrystals that form from a mixture of the RRI SS and RS/SR diastereoisomeric pairs of methyl 4-(2,4-dichlorophenyl)-2-methyl-7-phenyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate monohydrate, C 24 H 21 Cl 2 NO 3 ·-H 2 O. These compounds belong to a class of 1,4-dihydropyridines whose members have calcium modulatory properties. The 1,4-dihydropyridine rings have the usual shallow boat conformation. In each structure, the 2,4-dichlorophenyl ring is oriented such that the 2-chloro substituent is in a synperiplanar orientation with respect to the 1,4-dihydropyridine ring plane. In each crystal structure, the molecules are linked into chains by N-H···O hydrogen-bonding interactions.