Y. Hwang, H. Jeong
Jul 23, 2008
Citations
6
Influential Citations
139
Citations
Quality indicators
Journal
FEBS Letters
Abstract
In this study, we investigated the mechanisms of kahweol protection of neuronal cells from cell death induced by the Parkinson's disease‐related neurotoxin 6‐hydroxydopamine (6‐OHDA). Pretreatment of SH‐SY5Y cells with kahweol significantly reduced 6‐OHDA‐induced generation of ROS, caspase‐3 activation, and subsequent cell death. Kahweol also up‐regulated heme oxygenase‐1 (HO‐1) expression, which conferred neuroprotection against 6‐OHDA‐induced oxidative injury. Moreover, kahweol induced PI3K and p38 activation, which are involved in the induction of Nrf2, HO‐1 expression, and neuroprotection. These results suggest that regulation of the anti‐oxidant enzyme HO‐1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS.