M. Adamczyk, Donald D. Johnson, R. E. Reddy
Feb 26, 1999
Citations
1
Influential Citations
25
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract An efficient synthesis of tert -butyl-(2 S )-2-[( tert -butoxycarbonyl)amino]-4-(2-oxiranyl) butanoate ( 5 ), the key intermediate for preparation of collagen cross-links (+)-pyridinoline (Pyd, 1 ) and (+)-deoxypyridinoline (Dpd, 2 ) was described from (4 S )-5-( tert -butoxy)-4-[( tert -butoxycarbonyl)amino]-5-oxopentanoic acid ( 6 ) in six steps. Also, an improved synthesis of iodide (2 S )-(−)- 4b was presented.