R. Ostaszewski, D. E. Portlock, A. Fryszkowska
Jan 1, 2003
Citations
0
Influential Citations
11
Citations
Journal
Pure and Applied Chemistry
Abstract
Abstract A new synthetic method based on combination of enzymatic desymmetrization of 3-phenylglutaric anhydrides with multicomponent condensation is outlined. Enzymatic monoesterification of glutaric anhydrides was performed, and the derived monoacids were used as substrates for subsequent Ugi and Passerini multicomponent condensations. Both reactions were combined as two-step, one-pot processes. The choice of solvent and enzyme type has an appreciable effect on the course of reactions.