G. Uccello-Barretta, F. Balzano, G. Sicoli
Jan 15, 2004
Citations
1
Influential Citations
39
Citations
Journal
Bioorganic & medicinal chemistry
Abstract
NMR spectroscopic and molecular modelling methods have been employed to describe the complexation of trans-N-4-[N'-(4-chlorobenzoyl)hydrazinocarbonyl]cyclohexylmethyl-4-bromobenzenesulfonamide, a new chemotype of NPY-5 antagonist, and beta-cyclodextrin, revealing the coexistence of two different kinds of 1:1 complexes where conformational changes of the guest compound with respect to the free state are also detected.