Shao Jian-feng
2010
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Quality indicators
Journal
Journal of Huaihai Medicine
Abstract
Objective To explore the efficacy and safety of loxapine succinate and resperidone in treatment of patients with schizophrenia,so as to accumulate experiences for treating schizophrenia.Methods 62 patients with schizophrenia were randomly divided into a loxapine succinate group (n=31) and a resperidone group (n=31) for the treatment of 8 weeks.The efficacy and side effects were evaluated by Positive and Negative Symptom Scale (PANSS) and Treatment Emergent Symptoms Scale (TESS)before and after 2,4 and 8 treatmeat weeks.Results The effective rates of loxapine succinate and resperidone were 77.42% and 80.64% respectively,which showed no significant difference(P﹥0.05).The incidence of sleep disorders of the loxapine succinate group was lower than that of the resperidone group(P0.05). Conclusion Loxapine succinate is an effective drug for schizophrenia,with rapid efficacy and few side effects.