Chandak Shilpa, S. Dipak, Sharma Vimukta
Jun 26, 2012
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0
Influential Citations
14
Citations
Journal
ChemInform
Abstract
Pyrimidine derivatives play a vital role in many biological processes. Pyrimidine ring system is being present in nucleic acids, several vitamins, coenzymes, uric acid and some marine microorganisms (e.g. Sponge). The nitrogen heterocycles in general and pyrimidines in particular are found in several biologically active natural products and depict considerable therapeutic potential. Chalcone derivatives have been prepared by condensation of various substituted aryl aldehydes and acetophenone in alkaline ethanol, while pyrimidine-2-one derivatives have been prepared by the combination of chalcones and urea under conventional and ultrasonic conditions. The compound substituted ethyl-1,2,3,6-tetrahydro-4-methyl-2-oxo/thioxo-6-phenyl-1-(4,6-diphenyl-1Himidazolyl-2yl)pyrimidine-5-carboxylates have been synthesized by condensing substituted Benzil and enthyl-1-formyl-1,2,3,6-tetrahydro-4methyl-6-phenyl-2-oxo/thioxo-pyrimidine-5-carboxylates in the presence of ammonium acetate were dissolved in glacial acetic. The quinolinylpyrimidine derivatives were prepared by the condensation of quinolinyl chalcones with urea (or thiourea) under basic conditions by using both conventional and microwave heating. A beneficial ultrasound effect was observed and high yields of the products were obtained. Characterization and structural elucidation of the products have been done on the basis of chemical, analytical and spectral analysis. The newly prepared pyrimidine derivatives were screened for antimicrobial activities.