P. Jurkovic, M. Sentjurc, J. Kristl
2004
Citations
0
Influential Citations
9
Citations
Quality indicators
Journal
Journal of Drug Delivery Science and Technology
Abstract
Ascorbic acid and its derivatives are antioxidants and can be used for protecting skin against ultraviolet induced free radicals. In the present work, two ascorbic acid derivatives, hydrophilic sodium ascorbyl phosphate and amphiphilic ascorbyl palmitate, incorporated in microemulsions as carrier systems for dermal application, have been investigated and compared. Their effectiveness against free radical formation in porcine skin was determined with EPR spectroscopy using a spin trapping technique. Both antioxidants applied to the skin decreased the level of free radical formation. We showed that effectiveness of both derivatives was dependent on their concentration. For sodium ascorbyl phosphate the application time had also a significant influence on its effectiveness, while the effectiveness of ascorbyl palmitate depended primarily on the type of microemulsion.