K. Fabianowska-Majewska, D. Wyczechowska
Jul 1, 1997
Citations
0
Influential Citations
4
Citations
Quality indicators
Journal
Nucleosides, Nucleotides & Nucleic Acids
Abstract
Abstract The effect of 2-chloro-2′-deoxyadenosine and 9-β-D-arabinosyl-2-fluoro-adenine on metabolism of deoxyadenosine in human lymphocytes or erythrocytes was estimated. These drugs demonstrate different effects; 2CdA blocks both the dAdo phosphorylation and deamination (at 95% and 55%, respectively), while F-ara-A inhibits dAdo phosphorylation only at 40% and remains without effect on ADA activity.