J. Ermert, C. Hocke, Thomas Ludwig
Jun 1, 2004
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Influential Citations
57
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
The availability of no-carrier-added (n.c.a.) 1-bromo-4-[18F]fluorobenzene with high radiochemical yields is important for 18F-arylation reactions using metallo-organic 4-[18F]fluorophenyl compounds (e.g. of lithium or magnesium) or Pd-catalyzed coupling. In this study, different methods for the preparation of 1-bromo-4-[18F]fluorobenzene by nucleophilic aromatic substitution reactions using n.c.a. [18F]fluoride were examined. Of six pathways compared, symmetrical bis-(4-bromphenyl)iodonium bromide proved most useful to achieve the title compound in a direct, one-step nucleophilic substitution with a radiochemical yield (RCY) of 65% within 10 min. Copyright © 2004 John Wiley & Sons, Ltd.