E. E. Swanson, K. K. Chen
Jul 1, 1948
Citations
1
Influential Citations
12
Citations
Quality indicators
Journal
The Journal of pharmacology and experimental therapeutics
Abstract
1. A comparison of pressor action of 11 alicyclic ethyl and propyl amines has been made in pithed dogs. 2. The most active compound is 2-methylamino-1-cyclopentyl-propane. It has a long duration of action, and is effective in raising blood pressure in dogs by mouth. 3. 2-Methylamino-1-cyclopentyl-propane has the usual effects of sympathomimetic amines on smooth muscle organs. 4. 2-Methylamino-1-cyclopentyl-propane has an acute toxicity in mice by intravenous injection between that of ephedrine and amphetamine. Continuous administration of this compound in food to rats in concentrations varying from 0.01 to 0.1 per cent for a period of 27 days does not result in pathological changes of visceral organs.