Wang Jian-xi
2015
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Journal
Herald of Medicine
Abstract
Objective To study the stability of cefmenoxime hydrochloride for injection after mixing with fructose injection,invert sugar injection,invert sugar electrolyte injection,xylitol injection,or xylitol and sodium chloride injection.Methods The physical appearance,quantity of particles and p H were observed at room temperature after mixing cefmenoxime hydrochloride with each of above injections for 6 hours at concentrations simulated in clinical use. The content of cefmenoxime was determined by high performance liquid chromatography( HPLC). Results There was no significant difference in appearance,p H or cefmenoxime content after mixing 5 kinds of infusions for 6 hours,and the quantity of particles met the requirement.Conclusion Cefmenoxime is stable when dissolved in all 5 kinds of infusions.