K. Öster Svedberg, J. McKenzie, C. Larrivee-Elkins
Feb 1, 2002
Citations
0
Influential Citations
24
Citations
Journal
Journal of Clinical Pharmacy and Therapeutics
Abstract
Background: Ropivacaine hydrochloride (HCl) (`Naropin') is a long‐acting local anaesthetic agent, administered epidurally to patients undergoing various surgical procedures. A combination of local anaesthetic and opioid is often administered for the management of severe pain to ensure that a minimal dose of each is used. Ropivacaine might be used in combination with an αinf>2‐adrenergic agonist for the management of visceral pain. Stability data have shown that ropivacaine is compatible with the systemic narcotic opioid analgesics morphine sulphate, sufentanil citrate and fentanyl citrate for 14 days in a Polybag® (AstraZeneca‐AB, Sweden), but no data have been obtained for the longer‐term compatibility of ropivacaine with these opioids or with the αinf>2‐adrenergic agonist clonidine HCl.