M. Ohki, A. Takénaka, H. Shimanouchi
1977
Citations
0
Influential Citations
12
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
5-Bromocytosine and phthaloyl-DL-glutamic acid co-crystallize from their aqueous solution in space group P\bar1, with dimensions of a=10.578(2), b=19.640 (4), c=9.890 (3) A, α=88.13 (2), β=107.86 (3), γ=104.26 (1)°. Two molecular complexes and one water molecule are in an asymmetric unit. The structure was solved by the heavy atom method and refined by a block-diagonal least-squares method. The 5-bromocytosine molecule binds with γ-carboxyl group of the amino acid through NH···O and OH···O hydrogen bonds. In spite of largely different molecular environment in the crystal from that of 5-bromocytosine:N-tosyl-L-glutamic acid complex, the mode of interaction between the nucleotide base and the amino acid is the same. Thus, it is suggested that the present geometry is a typical binding mode between cytosine and acidic side group of amino acid.