D. Hesek, Mijoon Lee, B. Noll
Mar 20, 2009
Citations
2
Influential Citations
32
Citations
Journal
The Journal of organic chemistry
Abstract
Sodium hydride is a common reagent for substrate activation in nucleophilic substitution reactions. Sodium hydride can behave both as a base and as a source of hydride. This dual ability in the presence of an electrophile such as benzyl bromide results in the formation of byproducts when dimethylformamide or acetonitrile are used as solvents for these reactions. The structural nature of these byproducts is revealed in this report.