B. Kraiz, A. Remizov
2004
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Journal
Pharmaceutical Chemistry Journal
Abstract
Previously we showed [2] that the reaction between 2-hydroxymethyl-2-(2,4-dichloro-l,3,5triazin-6-yl)amino-l,3-propanediol (I) and benzaldehyde or veratraldehyde gave a mixture of the isomers of 2-phenylor 2-(3,4-dimethoxyphenyl)-5-hydroxymethyl-5-(2,4-dichloro-l,3,5triazin-6-yl)amino-!,3-dioxane (IV and V)~ The individual isomers, isolated from the mixture, differ only in the configuration of the substituents at C 5 of the 1,3-dioxane ring. The chromatographic mobility of the isomers on thin layers of alumina depends on the spatial structure of the particular isomer. To confirm that this is not a fortuitous relationship, we have undertaken the synthesis and study of the chromatographic mobility of the isomers of compounds II-XI. The partition coefficients of the isomers of VI-XIII in octanol-water were also determined.