B. Singh, R. G. Christiansen
Mar 1, 1971
Citations
0
Influential Citations
4
Citations
Journal
Journal of pharmaceutical sciences
Abstract
3-Methoxyspiro[estra-1,3,5(10)-triene-17,2′-oxetane] (17β-O) (IIIa) and tetrahydro-3-methoxyspiro[estra-1,3,5(10)-triene-17,2′-pyran](17β-O) (IIIb) were synthesized from 3-methoxy-19-nor-17β-pregna-1,3,5(10),20-tetraen-17-ol (IV) and 17-(4-hydroxy-1-butynyl)-3-methoxyestra-1,3,5(10)-trien-17β-ol(V). Additionally, IIIb was transformed into tetrahydrospiro[estr-5(10)-ene-17,2′-pyran]-3-one (17β-O) (VII) via tetrahydro-3-methoxyspiro[estra-2,5(10)-diene-17,2′-pyran] (17β-O) (VI).