E. V. Shilovskaya, I. I. Semina, R. I. Tarasova
Jul 1, 2013
Citations
0
Influential Citations
0
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
Application of computer modeling to a series of phosphorylated carboxylic acid derivatives revealed new compounds possessing high psychotropic activity, i.e., hydrazinium salts of phosphorylacetohydrazides. It was proved experimentally that these compounds contributed to the improvement of memory and learning processes, possessed antihypoxic properties, and exhibited antidepressant activity. The pharmacologically relevant pharmacophores in this group were the methyl and fluorine atom in the phosphoryl aryl radical. The obtained results confirmed the expediency of using a complex analysis of computer modeling of the structure–activity relationship and an experimental search for pharmacophores for scientifically justified prognosis and design of new drugs.