Tao Xu, Chuang-Chuang Li, Zhen Yang
Apr 27, 2011
Citations
0
Influential Citations
28
Citations
Journal
Organic letters
Abstract
A new strategy for the stereoselective total synthesis of natural product pseudolaric acid A (1) was accomplished in 16 steps from commercially available starting material, featuring a samarium diiodide (SmI(2))-mediated intramolecular alkene-ketyl radical cyclization and a ring-closing metathesis (RCM) reaction to stereoselectively cast the unusual trans-fused [5-7]-bicyclic core of pseudolaric acid A (1).