K. Mori, T. Kawasaki, T. Akiyama
Mar 5, 2012
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0
Influential Citations
67
Citations
Journal
Organic letters
Abstract
An expeditious route to furnish an isoquinoline skeleton via hydride shift mediated C-H bond functionalization was developed. In this process, an unusual [1,5]-H shift without the assistance of the adjacent heteroatom took place to produce tetrahydroisoquinoline derivatives in good to excellent chemical yields. The formal synthesis of (±)-tetrahydropalmatine was achieved by exploiting this new transformation.